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FOXBORO - Police Chief Edward O'Leary looked at his watch outside the town's new public safety building late Saturday afternoon, shook his head, and said Ann Killion had been missing for 25 hours.

Foxboro police, aided by officers from all over the area, along with search dogs and a state police helicopter, were all trying to find Killion, a 48-year-old Garfield Street resident who was last seen Friday afternoon outside of her home.

Killion is described as 6 feet tall and weighing around 275 pounds. She is believed to be wearing an orange sweatshirt and blue jeans, and is also believed to be highly medicated, according to a news release issued Saturday by police.

In an interview in the public safety complex's parking lot, which was being used as a command post and staging area, O'Leary said that teams had searched for Killion all day. As darkness began to fall over the area and temperatures started to drop, O'Leary and other officials were trying to determine whether to continue the search overnight.

Earlier Saturday, officers and K-9 teams fanned out in the area of Garfield Street, which is located less than a half-mile from the center of town off Route 140. O'Leary said 25 officers, along with seven search dog teams working in grid patterns, searched for Killion throughout the day.

Groups of specially trained officers from the Metropolitan Law Enforcement Council, a regional police response team, fanned out across the area to search for the woman around homes and in other areas.

Twice, police used the town's reverse 911 emergency phone system to call all the phones within a one-mile radius of Killion's Garfield Street home, and alert them to her apparent disappearance, the chief said.

O'Leary said a state police helicopter had been used earlier in the day, with officials hoping that Killion's orange sweatshirt could be identified from the air. She wasn't spotted.

Lyn Moraghan, an Ashland Fire Department paramedic, who was assisting along with her search dog, an Australian shepherd named Dublyn, said she and other dog teams searched for the missing woman in both residential and wooded places, including the area of Chestnut Street, a local cemetery, and around the town's water tank.

Moraghan, who is affiliated with the Massachusetts Canine Response Team, said that her four-legged partner Dublyn is trained to pick up the scents of humans - not one scent unique to a single missing person, but rather the scent of all humans.

She said that after undergoing rigorous training that took nearly two years, Dublyn is able to methodically work a search area off a leash.